sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin)

N/A

IgG

N/A

N/A

N/A

N/A

Human

sRANKL

Polyclonal

Antibodies

Biotinylated

Polyclonal antibody

Host: Goat; Source: Human

Recognizes human soluble RANKL.

ELISA (EL/EIA), Western Blot (WB)

Affinity Purified by immunoaffinity chromatography.

sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin)

sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin)

Anti-sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin)

Anti -sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin)

Supplied as a lyophilized powder from a sterile-filtered PBS solution. Conjugated to Biotin.

Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.

In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

Lyophilized powder Store at 4 degrees Celsius for short term storage.. Reconstitute to nominal volume by adding sterile 40-50% glycerol and For optimal long term storage, productone should be kept at -20 degrees Celsius. Reconstituted product is stable for 12 months productone should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory

FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.