Important information

Name

sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin) Antibody

Size

0.025 miligrams

Catalog number

MBS610170

Price

426 €

Extended information

Other names

N/A

Gene name

N/A

Gene name synonims

N/A

Other gene names

N/A

Immunoglobulin isotype

IgG

Concentration

N/A

Species reactivity

Human

Alternative name4

sRANKL

French translation

anticorps

Category

Antibodies

Clonality

Polyclonal

Conjugation

Biotinylated

Specificity and cross-reactivity

Recognizes sRANKL

Clone

Polyclonal antibody

Host organism

Host: Rabbit; Source: Human

Storage and shipping

Store productone at -20 degrees Celsius.

Tested for:

ELISA (EL/EIA), Western Blot (WB), Neutralization

Purification method

Affinity Purified by antigen affinity chromatography.

Alternative name2

sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin)

Alternative name3

sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin)

Alternative name1

Anti-sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin)

Alternative name5

Anti -sRANKL (soluble RANK Ligand, Receptor Activator of NFkB Ligand) (Biotin)

Form/Appearance

Supplied as a lyophilized powder from a sterile-filtered solution in PBS, pH 7.4, conjugated to biotin.

Advisory

In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

Properties

If you buy Antibodies supplied by MBS Polyclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.

Description

productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.

Gene

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory

Additional description

FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.