Important information

Name

Recombinant Human RANK/TNFRSF11A/CD265 Protein(C-6His)

Size

10µg

Catalog number

PKSH032987-10µg

Price

129 €

Extended information

Activity

NA

Fusion tag

C-6His

Accession

Q9Y6Q6

Mol Mass

21.1 kDa

AP Mol Mass

25-30 kDa

Expressed Host

Human cells

Group

recombinants

Sequence

Ile30-Pro212

Source

Recombinants or rec. proteins

Purity

>95% as determined by reducing SDS-PAGE.

Endotoxin

<1.0 EU per µg as determined by LAL test.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability and Storage

Lyophilized protein should be stored at <-20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at <-20℃ for 3 months

Synonym

CD265; ODFR; TNFRSF11A; TRANCE R; CD265; CD265 antigen; FEO; ODFROSTS; OFE; OPTB7; PDB2; RANK1; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TRANCER; tumor necrosis factor receptor superfamily member 11A

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Background

Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.