RANK Antibody

RANK

O35305

Antibody

WB, ELISA

anticorps

Unconjugated

Antigen affinity

Polyclonal antibody

Antigen affinity purified

Polyclonal (rabbit origin)

Western blot: 0.1-0.5ug/ml

Rabbit (Oryctolagus cuniculus)

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Optimal dilution of the RANK antibody should be determined by the researcher.

Amino acids 35-214 of mouse RANK were used as the immunogen for the RANK antibody.

This RANK antibodyis to be used only for research purposes and not for diagnostics..

If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.

After reconstitution, the RANK antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.

Receptor Activator of NFkB (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. RANKL (Receptor Activator for NFkB Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.