Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein

NA

18 kDa

O35235

E.coli

20.1 kDa

recombinants

Mus musculus

Gln137-Asp316

Recombinants or rec. proteins

＞95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20mMTris,150mMNaCl,1mMEDTA,pH8.0.

Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells.The ED50 for this effect is less than 2 ng/mL..

Tumor necrosis factor ligand superfamily member 11;Tnfsf11;Osteoclast differentiation factor;ODF;Osteoprotegerin ligand;OPGL;Receptor activator of nuclear factor kappa-B ligand;RANKL;TNF-related activation-induced cytokine;TRANCE;CD254

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.